Enzymatic synthesis of palm-based kojic acid monooleate in stirred tank reactor was carried out via esterification of kojic acid and oleic acid catalysed by  Lipozyme  RMIM.  The influence of substrate concentration was investigated over a wide range (1.0–4.0 mmol/mL). The reaction kinetics pattern follows a Ping-Pong Bi-Bi mechanism with dead-end inhibition by palm-based oleic acid substrate. Based on the proposed model, the kinetic constants of the esterification reaction are characterised by the, Km(KA), Km(OA) and Ki(OA) with the values of 45.8 mmol/L.h.g, 1.87 × 10^-7  mmol/L.g, 8.31 × 10²  mmol/L.g and 5.32 × 10⁶  mmol/L.g, respectively.